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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC8
All Species:
17.88
Human Site:
S13
Identified Species:
24.58
UniProt:
Q9BY41
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.19
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BY41
NP_060956.1
377
41758
S13
E
P
A
D
S
G
Q
S
L
V
P
V
Y
I
Y
Chimpanzee
Pan troglodytes
XP_001140380
415
46624
S51
E
P
A
D
S
G
Q
S
L
V
P
V
Y
I
Y
Rhesus Macaque
Macaca mulatta
XP_001093861
377
41783
S13
E
P
A
D
S
G
Q
S
L
I
P
V
Y
I
Y
Dog
Lupus familis
XP_538078
377
41675
S13
E
P
A
E
S
G
Q
S
L
P
P
V
Y
I
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8VH37
377
41753
S13
E
P
A
N
S
G
H
S
L
P
P
V
Y
I
Y
Rat
Rattus norvegicus
Q4QQW4
482
55074
V11
T
Q
G
T
K
R
K
V
C
Y
Y
Y
D
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510728
773
87357
R307
P
H
G
V
K
T
P
R
L
P
P
V
Y
I
Y
Chicken
Gallus gallus
P56517
480
54920
V11
T
Q
G
T
K
R
K
V
C
Y
Y
Y
D
G
D
Frog
Xenopus laevis
O42227
480
54874
V11
S
Q
G
T
K
K
K
V
C
Y
Y
Y
D
G
D
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
P11
R
T
A
Y
F
Y
D
P
D
V
G
N
F
H
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
Y11
H
S
K
K
R
V
C
Y
Y
Y
D
S
D
I
G
Honey Bee
Apis mellifera
XP_394976
461
52425
M27
M
K
P
H
R
I
R
M
T
H
N
L
L
L
N
Nematode Worm
Caenorhab. elegans
O17695
461
52119
R14
L
M
E
H
G
K
R
R
V
A
Y
Y
Y
D
S
Sea Urchin
Strong. purpuratus
P56518
576
64060
Y12
G
T
K
K
R
V
C
Y
Y
Y
D
G
D
V
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
R24
G
P
D
G
Q
K
R
R
V
C
Y
F
Y
D
P
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H0W2
426
48669
D12
D
K
I
S
Y
F
Y
D
G
D
V
G
S
V
Y
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
R20
V
K
P
S
D
K
R
R
V
A
Y
F
Y
D
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.9
99.1
97.6
N.A.
96.2
32.7
N.A.
44.2
32.5
33.3
37.3
N.A.
30.1
35.1
34.4
27.7
Protein Similarity:
100
87.7
99.7
99.1
N.A.
98.1
50.2
N.A.
47.3
50
50.6
56.3
N.A.
46.6
54
51.4
42.3
P-Site Identity:
100
100
93.3
86.6
N.A.
80
0
N.A.
40
0
0
20
N.A.
6.6
0
6.6
0
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
6.6
N.A.
40
6.6
6.6
26.6
N.A.
6.6
20
20
6.6
Percent
Protein Identity:
N.A.
33.3
N.A.
38.5
36.4
N.A.
Protein Similarity:
N.A.
48.1
N.A.
57.2
55.4
N.A.
P-Site Identity:
N.A.
13.3
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
36
0
0
0
0
0
0
12
0
0
0
0
6
% A
% Cys:
0
0
0
0
0
0
12
0
18
6
0
0
0
0
0
% C
% Asp:
6
0
6
18
6
0
6
6
6
6
12
0
30
18
18
% D
% Glu:
30
0
6
6
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
6
6
0
0
0
0
0
12
6
0
0
% F
% Gly:
12
0
24
6
6
30
0
0
6
0
6
12
0
18
12
% G
% His:
6
6
0
12
0
0
6
0
0
6
0
0
0
6
0
% H
% Ile:
0
0
6
0
0
6
0
0
0
6
0
0
0
42
0
% I
% Lys:
0
18
12
12
24
24
18
0
0
0
0
0
0
0
0
% K
% Leu:
6
0
0
0
0
0
0
0
36
0
0
6
6
6
0
% L
% Met:
6
6
0
0
0
0
0
6
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
6
0
0
0
0
0
0
6
6
0
0
6
% N
% Pro:
6
36
12
0
0
0
6
6
0
18
36
0
0
0
6
% P
% Gln:
0
18
0
0
6
0
24
0
0
0
0
0
0
0
0
% Q
% Arg:
6
0
0
0
18
12
24
24
0
0
0
0
0
0
0
% R
% Ser:
6
6
0
12
30
0
0
30
0
0
0
6
6
0
6
% S
% Thr:
12
12
0
18
0
6
0
0
6
0
0
0
0
0
0
% T
% Val:
6
0
0
6
0
12
0
18
18
18
6
36
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
6
6
6
6
12
12
30
36
24
53
0
48
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _